The effect of oral omeprazole on the disposition of lignocaine
| Autor: | D. W. Noble, J. Bannister, D.B. Scott, Lamont M, T. Andersson |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Lidocaine business.industry Local anesthetic medicine.drug_class Administration Oral Drug interaction Placebo Crossover study Anesthesiology and Pain Medicine Double-Blind Method Pharmacokinetics Oral administration Anesthesia medicine Humans Drug Interactions business Omeprazole medicine.drug |
| Zdroj: | Anaesthesia. 49:497-500 |
| ISSN: | 1365-2044 0003-2409 |
| DOI: | 10.1111/j.1365-2044.1994.tb03519.x |
| Popis: | Summary The effects of the gastric antisecretory drug, omeprazole, on the disposition of lignocaine were studied in 10 healthy male volunteers in a double-blind, randomised, placebo-controlled, two-period crossover trial. Omeprazole 40 mg or placebo was taken daily for one week before administration of lignocaine 1 mg.kg-1 (3.7 μmol.kg-1) given intravenously over 10 min. Venous concentrations of lignocaine and its metabolite monoethylglycinexylidine were measured in plasma with reversed phase liquid chromatography. The mean (95% CI) areas under the curve at infinity for lignocaine after pretreatment with omeprazole or placebo were 6.67 (4.90–8.45) μmol.h.l-1 and 6.14 (5.05-7.23) μmol.h.l-1, respectively (p = 0.44). The respective areas for monoethylglycinexylidine were 1.85 (1.25-2.45) μmol.h.l-1 and 1.79 (1.44-2.14) μmol.h.r-1 (p = 0.78). Similarly, omeprazole had no significant effect on the half-lives of lignocaine or methylglycinexylidine. |
| Databáze: | OpenAIRE |
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