Distinct susceptibility of developing neurons to death following Bax overexpression in the chicken embryo
| Autor: | Noboru Sato, Ronald W. Oppenheim, Hiroyuki Yaginuma, Chie Sakuma, T W Gould, Y Sato |
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| Rok vydání: | 2005 |
| Předmět: |
Programmed cell death
Period (gene) Genetic Vectors Apoptosis Chick Embryo Retina Cell Line chemistry.chemical_compound Retrovirus In vivo otorhinolaryngologic diseases medicine Animals Neurons Afferent Molecular Biology bcl-2-Associated X Protein Motor Neurons biology Retinal Embryo Cell Biology Motor neuron Spinal cord biology.organism_classification Cell biology medicine.anatomical_structure Retroviridae chemistry Spinal Cord Mutation |
| Zdroj: | Cell death and differentiation. 13(3) |
| ISSN: | 1350-9047 |
| Popis: | Bax is a proapoptotic protein that is required for programmed cell death (PCD) of many neuronal populations. Here we show that, during an early period of retinal PCD and in naturally occurring sensory and motor neuron (MN) death in the spinal cord, Bax delivery results in enhanced death of these neural populations. In contrast, Bax overexpression fails to enhance an early phase of MN death that occurs in the cervical spinal cord, although overexpressed Bax appears to be activated in dying MNs. Bax overexpression does not also affect the survival of immature neurons prior to the PCD period. Taken together, these data provide the first in vivo evidence suggesting that Bax appears to act selectively as an executioner only in neurons undergoing PCD. Furthermore, although Bax appears to mediate the execution pathway for PCD, the effect of Bax overexpression on susceptibility to death differs between different neuronal populations. |
| Databáze: | OpenAIRE |
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