Population differences in S-warfarin pharmacokinetics among African Americans, Asians and whites: their influence on pharmacogenetic dosing algorithms

Autor:	A. Miyajima, Larisa H. Cavallari, Yuan-Tsong Chen, Roberto Padrini, N. Kaneko, Ming-Shien Wen, Maria Gabriella Scordo, K. Kubo, Minami Ohara, Harumi Takahashi, Edith A. Nutescu, M. Tachikawa, Ming Ta Michael Lee, Vittorio Pengo, Minoli A. Perera
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	Male Genotype Pharmacogenomic Variants Metabolic Clearance Rate Molecular Medicine Genetics Pharmacology Population 030204 cardiovascular system & hematology Models Biological Polymorphism Single Nucleotide White People Cohort Studies 03 medical and health sciences 0302 clinical medicine Asian People Vitamin K Epoxide Reductases medicine Humans 030212 general & internal medicine Dosing education CYP2C9 Cytochrome P-450 CYP2C9 education.field_of_study Dose-Response Relationship Drug business.industry Warfarin Anticoagulants Middle Aged Pharmacogenomic Testing Black or African American Cohort Female VKORC1 business Algorithm Pharmacogenetics Algorithms medicine.drug Cohort study
Popis:	Using population pharmacokinetic analysis (PPK), we attempted to identify predictors of S-warfarin clearance (CL(S)) and to clarify population differences in S-warfarin pharmacokinetics among a cohort of 378 African American, Asian and white patients. Significant predictors of CL(S) included clinical (age, body weight and sex) and genotypic (CYP2C9*2,*3 and *8) factors, as well as African American ethnicity, the median CL(S) being 30% lower in the latter than in Asians and whites (170 versus 243 and 250 ml h-1, P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471af3641f3eeae94e4cc1a692bb09b9 http://hdl.handle.net/11577/3212413 Zobrazit plný text záznamu