| Autor: |
Lavinia Carmen Uscătescu, Martin Kronbichler, Sarah Said-Yürekli, Lisa Kronbichler, Vince Calhoun, Silvia Corbera, Morris Bell, Kevin Pelphrey, Godfrey Pearlson, Michal Assaf |
| Rok vydání: |
2022 |
| DOI: |
10.1101/2022.06.26.497652 |
| Popis: |
Intrinsic neural timescales (INT) reflect the duration for which brain areas store information. A posterior – anterior hierarchy of increasingly longer INT has been revealed in both typically developed individuals (TD), as well as patients diagnosed with autism spectrum disorder (ASD) and schizophrenia (SZ), though INT are, overall, shorter in both patient groups. In the present study, we attempted to replicate previously reported group differences by comparing INT of TD to ASD and SZ. We replicated the previously reported result showing reduced INT in the left lateral occipital gyrus and the right post-central gyrus in SZ compared to TD. For the first time, we also directly compared the INT of the two patient groups and found that these same two areas show significantly reduced INT in SZ compared to ASD. In ASD, significant correlations were found between INT and their clinical and phenotypic characteristics. Our results point to the left lateral occipital gyrus and the right post-central gyrus as holding potential for further diagnostic refinement of SZ. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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