The Dose-Response Effect of Lycopene on Cerebral Vessel and Neuron Impairment Induced by Hyperlipidemia
| Autor: | Weichun Yang, Minyu Hu, Wei Wang, Sixian Wen, Ziyi Shen |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty VEGF receptors Hyperlipidemias Hippocampal formation Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Lycopene Response effect Internal medicine Hyperlipidemia medicine Animals Humans Claudin-5 CA1 Region Hippocampal Triglycerides Neurons biology Dose-Response Relationship Drug Brain General Chemistry Serum concentration medicine.disease Rats 030104 developmental biology medicine.anatomical_structure Endocrinology chemistry biology.protein Blood Vessels Female Neuron Cerebral vessel General Agricultural and Biological Sciences 030217 neurology & neurosurgery |
| Zdroj: | Journal of agricultural and food chemistry. 66(50) |
| ISSN: | 1520-5118 |
| Popis: | To study the dose-response effect of lycopene on vessel and neuron damage in the brain against hyperlipidemia, rats were fed with hypercholesterolemic feed and treated with lycopene orally by gavage at the dose of 5, 25, 45, 65, 85, and 105, 125 mg/kg/bw-1/d-1. At the end of the fourth week, lycopene doses and serum lycopene concentration showed an inverse U-shape curve. Serum lycopene concentration was negatively correlated with the levels of serum TC, TG, LDL-C, as well as the cerebral LDL-C, VEGF, and VCAM-1. Serum lycopene concentration was positively correlated with the expression of Claudin-5 and the number of neurons in hippocampal CA1 and CA3. Lycopene could also reduce the pathologic change of these areas. These results suggested an inverse U-shape relation between dose and serum concentration of lycopene, and intermediate doses were most effective to protect cerebral vessels and neurons from being damaged by hyperlipidemia. |
| Databáze: | OpenAIRE |
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