Antiproliferative Activity of Cyanophora paradoxa Pigments in Melanoma, Breast and Lung Cancer Cells
| Autor: | Jean-Paul Cadoret, Raymond Kaas, Anne-Laure Gagez, Jean-Baptiste Bérard, Valérie Thiéry, Nicolas Bridiau, Camille Juin, Laurent Picot, Paul-Hubert Baudelet |
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| Přispěvatelé: | LIttoral ENvironnement et Sociétés - UMRi 7266 (LIENSs), Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS), Physiologie et biotechnologie des Algues (PBA), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Lung Neoplasms
Skin Neoplasms Pharmaceutical Science Xanthophylls 01 natural sciences pigments microalgae Cyanophora paradoxa melanoma cancer apoptosis zeaxanthin cryptoxanthin chemistry.chemical_compound Drug Discovery Cytotoxicity lcsh:QH301-705.5 Pharmacology Toxicology and Pharmaceutics (miscellaneous) Cryptoxanthins 0303 health sciences Cyanophora Biochemistry MCF-7 Cells Female Antineoplastic Agents Breast Neoplasms Biology Article 03 medical and health sciences Zeaxanthins Cell Line Tumor medicine Humans [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM] Cell Proliferation 030304 developmental biology Allophycocyanin Cancer Pigments Biological medicine.disease biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry lcsh:Biology (General) chemistry Cell culture Pheophorbide A Cancer cell |
| Zdroj: | Marine drugs Marine drugs, MDPI, 2013, 11 (11), pp.4390-4406 Marine Drugs (1660-3397) (Mdpi Ag), 2013-11, Vol. 11, N. 11, P. 4390-4406 Marine Drugs Marine Drugs; Volume 11; Issue 11; Pages: 4390-4406 Marine Drugs, Vol 11, Iss 11, Pp 4390-4406 (2013) |
| ISSN: | 1660-3397 |
| Popis: | International audience; The glaucophyte Cyanophora paradoxa (Cp) was chemically investigated to identify pigments efficiently inhibiting malignant melanoma, mammary carcinoma and lung adenocarcinoma cells growth. Cp water and ethanol extracts significantly inhibited the growth of the three cancer cell lines in vitro, at 100 µg·mL−1. Flash chromatography of the Cp ethanol extract, devoid of c-phycocyanin and allophycocyanin, enabled the collection of eight fractions, four of which strongly inhibited cancer cells growth at 100 µg·mL−1. Particularly, two fractions inhibited more than 90% of the melanoma cells growth, one inducing apoptosis in the three cancer cells lines. The detailed analysis of Cp pigment composition resulted in the discrimination of 17 molecules, ten of which were unequivocally identified by high resolution mass spectrometry. Pheophorbide a, β-cryptoxanthin and zeaxanthin were the three main pigments or derivatives responsible for the strong cytotoxicity of Cp fractions in cancer cells. These data point to Cyanophora paradoxa as a new microalgal source to purify potent anticancer pigments, and demonstrate for the first time the strong antiproliferative activity of zeaxanthin and β-cryptoxanthin in melanoma cells. |
| Databáze: | OpenAIRE |
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