Edible seaweed-derived constituents: an undisclosed source of neuroprotective compounds
| Autor: | Dieter Lütjohann, Assia Tiane, Monique T. Mulder, Hong-Bing Liu, Kenneth Vanbrabant, Tim Vanmierlo, Melissa Schepers, Nikita Martens |
|---|---|
| Přispěvatelé: | Internal Medicine |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
phytosterols polysaccharides Review phenols Systemic circulation Neuroprotection lcsh:RC346-429 03 medical and health sciences 0302 clinical medicine Developmental Neuroscience algae carotenoids neuro-active seaweed BRAIN Carotenoid lcsh:Neurology. Diseases of the nervous system chemistry.chemical_classification PLANT STEROLS SARGASSUM-FUSIFORME Chemistry CHOLESTEROL ASCOPHYLLUM-NODOSUM ALPHA-GLUCOSIDASE ALZHEIMERS-DISEASE Edible seaweed POLYSACCHARIDE 030104 developmental biology Biochemistry Corrigendum AMYLASE BROWN-ALGAE 030217 neurology & neurosurgery |
| Zdroj: | Neural Regeneration Research Neural Regeneration Research, 15(5), 790-795. Wolters Kluwer Medknow Neural Regeneration Research, Vol 15, Iss 5, Pp 790-795 (2020) |
| ISSN: | 1673-5374 |
| DOI: | 10.4103/1673-5374.268894 |
| Popis: | Edible marine algae, or seaweeds, are a rich source of several bioactive compounds including phytosterols, carotenoids, and polysaccharides. Over the last decades, seaweed-derived constituents turned out to not only reside in the systemic circulation, but are able to cross the blood-brain barrier to exert neuro-active functions both in homeostatic and pathological conditions. Therefore, seaweed-derived constituents have gained increasing interest for their neuro-immunomodulatory and neuroprotective properties, rendering them interesting candidates for the management of several neurodegenerative disorders. In particular seaweed-derived phytosterols gained interest for the treatment of neurodegenerative disorders as they potentiate neuroplasticity, enhance phagocytic clearance of neurotoxic peptides and have anti-inflammatory properties. Though, the anti-inflammatory and anti-oxidative properties of other constituents including carotenoids, phenols and polysaccharides have recently gained more interest. In this review, we provide an overview of a selection of the described neuro-active properties of seaweed-derived constituents with a focus on phytosterols. |
| Databáze: | OpenAIRE |
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