Stability of meropenem in intravenous solutions
| Autor: | Steven E. Cook, Piyush R. Patel |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Sodium Sodium Chloride Injection Drug Storage chemistry.chemical_element Sodium Chloride Diluent Meropenem chemistry.chemical_compound Drug Stability medicine Drug packaging Chromatography High Pressure Liquid Drug Packaging Antibacterial agent Pharmacology Chromatography Intravenous solutions Health Policy Temperature Surgery Solutions Polyvinyl chloride chemistry Injections Intravenous Thienamycins medicine.drug |
| Zdroj: | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 54(4) |
| ISSN: | 1079-2082 |
| Popis: | The stability of meropenem in various i.v. fluids stored in various containers for i.v. use was studied. Solutions of meropenem were prepared in a variety of i.v. diluents in polyvinyl chloride (PVC) bags, glass vials, and commercial easy-to-prepare infusion systems. Solutions for storage in PVC bags were prepared with meropenem concentrations of 1 and 20 mg/mL; in glass vials, 2.5 and 50 mg/mL; and in commercial easy-to-prepare infusion systems, 2.5 and 20 mg/mL (Baxter Minibag Plus system) and 1, 5, and 20 mg/mL (ADD-Vantage system, Abbott). The solutions were stored for up to 48 hours at 4-5 or 21-26 degrees C. Meropenem concentrations were determined by high-performance liquid chromatography. The stability of meropenem was influenced by the drug concentration; the drug was stable for a longer time in the 1-mg/mL solution than in the 20- and 50-mg/mL solutions. Stability was also influenced by storage temperature; the drug was stable for a longer time in solutions stored at 4-5 degrees C than in solutions stored at 21-26 degrees C. Meropenem was stable for the longest time in sterile water for injection and in 0.9% sodium chloride injection. The stability of meropenem in solutions in PVC bags, glass vials, Baxter Minibag Plus containers, and ADD-Vantage bags was influenced by the i.v. fluid used to reconstitute the drug, the concentration of the final solution, and the storage temperature. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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