A Novel Human Polyomavirus Closely Related to the African Green Monkey-Derived Lymphotropic Polyomavirus
Autor: | Sébastien Calvignac-Spencer, Klemens Ruprecht, Nelly Scuda, Jörg Hofmann, Hartmut Hengel, Joachim E. Kühn, Bernhard Ehlers, Peter Liman |
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Rok vydání: | 2011 |
Předmět: |
Tumor Virus Infections
viruses Molecular Sequence Data Immunology Sequence Homology Biology Kidney medicine.disease_cause Microbiology Virus Immunocompromised Host Virology Chlorocebus aethiops medicine Animals Cluster Analysis Humans Phylogeny Human polyomavirus 6 Genetics Polyomavirus Infections Transplantation Sequence Analysis DNA biology.organism_classification Polyomaviridae Genetic Diversity and Evolution Insect Science DNA Viral African Green Monkey Polyomavirus Nested polymerase chain reaction |
Zdroj: | Journal of Virology. 85:4586-4590 |
ISSN: | 1098-5514 0022-538X |
DOI: | 10.1128/jvi.02602-10 |
Popis: | We identified a novel human polyomavirus from a kidney transplant patient under immunosuppressive treatment, by use of a generic PCR. The genome of the virus was completely amplified and sequenced. In phylogenetic analyses, it appeared as the closest relative to the African green monkey-derived lymphotropic polyomavirus (LPV). Further investigation of clinical samples from immunocompromised patients with specific nested PCR revealed additional positive samples, indicating that the virus naturally infects humans. The virus was tentatively named human polyomavirus 9 (HPyV9). The previously observed seroreactivity to LPV in human populations might find a partial explanation in the circulation of HPyV9. |
Databáze: | OpenAIRE |
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