The Diabetes Visual Function Supplement Study (DiVFuSS)
| Autor: | Jeffry D Gerson, Renu A. Kowluru, Stuart P Richer, A Paul Chous |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
0301 basic medicine Visual acuity Visual Acuity Type 2 diabetes Xanthophylls Antioxidants 0302 clinical medicine Prospective Studies Vitamin D biology Macula Diabetic retinopathy Clinical Science Middle Aged Clinical Trial Lipids Sensory Systems C-Reactive Protein Female medicine.symptom Retinopathy Adult medicine.medical_specialty Vision Disorders Placebo Retina Contrast Sensitivity 03 medical and health sciences Cellular and Molecular Neuroscience Diabetes mellitus Ophthalmology medicine Humans Aged Glycated Hemoglobin Diabetic Retinopathy Colour vision Tumor Necrosis Factor-alpha business.industry C-reactive protein medicine.disease Field of vision Diabetes Mellitus Type 1 030104 developmental biology Peripheral neuropathy Diabetes Mellitus Type 2 Dietary Supplements 030221 ophthalmology & optometry biology.protein Macular Pigment Visual Fields business Phytotherapy |
| Zdroj: | The British Journal of Ophthalmology |
| ISSN: | 1468-2079 0007-1161 |
| DOI: | 10.1136/bjophthalmol-2014-306534 |
| Popis: | Background Diabetes is known to affect visual function before onset of retinopathy (diabetic retinopathy (DR)). Protection of visual function may signal disruption of mechanisms underlying DR. Methods This was a 6-month randomised, controlled clinical trial of patients with type 1 and type 2 diabetes with no retinopathy or mild to moderate non-proliferative retinopathy assigned to twice daily consumption of placebo or a novel, multi-component formula containing xanthophyll pigments, antioxidants and selected botanical extracts. Measurement of contrast sensitivity, macular pigment optical density, colour discrimination, 5-2 macular threshold perimetry, Diabetic Peripheral Neuropathy Symptoms, foveal and retinal nerve fibre layer thickness, glycohaemoglobin (HbA1c), serum lipids, 25-OH-vitamin D, tumour necrosis factor α (TNF-a) and high-sensitivity C reactive protein (hsCRP) were taken at baseline and 6 months. Outcomes were assessed by differences between and within groups at baseline and at study conclusion using meand ± SDs and t tests (p |
| Databáze: | OpenAIRE |
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