EXPAREL® (Long-Acting Liposomal Bupivacaine) Use for Popliteal Nerve Block in Postoperative Pain Control after Ankle Fracture Fixation
| Autor: | Swetha Y Sanghvi, Keith D. Cook, Minho Kwon, Anna Korban, Jean Daniel Eloy, Ross E Moore, Patrick Discepola, Mohamed Bouhara, Trevor A. Whitwell, Bilal A Siddiqui |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Medicine (General) Article Subject Popliteal fossa Analgesic 03 medical and health sciences R5-920 0302 clinical medicine 030202 anesthesiology Fracture fixation medicine Humans Pain Management Ankle Injuries Prospective Studies Anesthetics Local Prospective cohort study Bupivacaine Pain Postoperative business.industry Nerve Block Middle Aged Liposomal Bupivacaine Clinical trial Open Fracture Reduction Anesthesiology and Pain Medicine medicine.anatomical_structure Neurology 030220 oncology & carcinogenesis Anesthesia Female Ankle business Research Article medicine.drug |
| Zdroj: | Pain Research & Management Pain Research and Management, Vol 2020 (2020) |
| ISSN: | 1918-1523 1203-6765 |
| DOI: | 10.1155/2020/5982567 |
| Popis: | EXPAREL® has been used successfully to prolong postoperative pain control when applied as a wound infiltrate. EXPAREL® has not yet been approved for use in regional anesthesia to prolong postoperative pain control. We conducted a clinical case series of 4 patients using EXPAREL® for sciatic blocks via the popliteal fossa approach. Our results suggested that there is a large degree of variability in response to the medication. These inconsistent results and the possibility of bimodal kinetics creating analgesic gaps as seen in two of our patients indicate that more studies with larger sample size are needed to better characterize these phenomena and determine if more consistent results can be obtained in a future clinical trial. |
| Databáze: | OpenAIRE |
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