Strawberry (Fragaria ananassa duch.) Alba extract attenuates DNA damage in lymphocytes of patients with Alzheimer’s disease
| Autor: | Dragana Dekanski, Andrea Čabarkapa-Pirković, Mirjana Zlatkovic-Svenda, Lada Živković, Vladan Bajic, Biljana Spremo-Potparević, George Perry, Tamara Y. Forbes-Hernandez |
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| Rok vydání: | 2021 |
| Předmět: |
030309 nutrition & dietetics
DNA damage Biophysics Endogeny Pharmacology Biology medicine.disease_cause Fragaria 03 medical and health sciences 0404 agricultural biotechnology neurodegenerative disease Alzheimer Disease In vivo comet assay medicine Humans Lymphocytes Aged 2. Zero hunger 0303 health sciences Plant Extracts 04 agricultural and veterinary sciences Cell Biology 040401 food science In vitro Comet assay Ageing ageing Oxidative stress DNA Damage Food Science |
| Zdroj: | Journal of Food Biochemistry |
| Popis: | Increased levels of oxidative stress and oxidative DNA damage are common features in the pathology of Alzheimer’s disease (AD) found in neurons and peripheral cells like peripheral blood lymphocytes (PBL). Natural products such as strawberry cultivar Alba are an important source of bioactive nutrients that could help in lowering both the oxidative stress and DNA damage levels. The objective was to estimate the effects of Alba extract on DNA damage in peripheral blood lymphocytes of sporadic AD (aged 60–84 years) patients, and healthy elderly (aged 69–83 years) and young (aged 21–30 years) individuals in in vitro conditions. Comet assay was used as a sensitive technique for the evaluation of PBL DNA damage levels. Reduction of basal DNA damage level in PBL was shown in the young group after the incubation with Alba extract ranging from 25 to 200 μg/ml, with 100 μg/ml being the most effective concentration. Selected Alba extract of 100 μg/ml was further used for PBL treatment of AD and healthy elderly age matched group, displaying potential to significantly attenuate DNA damage levels in both groups (p |
| Databáze: | OpenAIRE |
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