Distinct phenotype of CD4+ T cells driving celiac disease identified in multiple autoimmune conditions

Autor:	Elsa Sola, Omri Snir, Julia F. Simard, Chakravarthi Kanduri, Ludvig M. Sollid, Shiva Dahal-Koirala, Paul J. Utz, Knut E.A. Lundin, Stephanie Zühlke, Mark M. Davis, Cornelia L. Dekker, Asbjørn Christophersen, Eivind G. Lund, Mina Rohani-Pichavant, Øyvind Molberg
Rok vydání:	2019
Předmět:	0301 basic medicine Lupus erythematosus business.industry RNA nutritional and metabolic diseases General Medicine Disease medicine.disease Phenotype General Biochemistry Genetics and Molecular Biology Scleroderma digestive system diseases 3. Good health 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Immunophenotyping Antigen 030220 oncology & carcinogenesis Immunology medicine Mass cytometry business
ISSN:	1078-8956
Popis:	Combining HLA-DQ-gluten tetramers with mass cytometry and RNA sequencing analysis, we find that gluten-specific CD4+ T cells in the blood and intestines of patients with celiac disease display a surprisingly rare phenotype. Cells with this phenotype are also elevated in patients with systemic sclerosis and systemic lupus erythematosus, suggesting a way to characterize CD4+ T cells specific for disease-driving antigens in multiple autoimmune conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::470c093cfb0652ff5494c3d8c6313b2e http://hdl.handle.net/10852/74538 Zobrazit plný text záznamu Full text from SpringerLink