Kaposi's Sarcoma Complicating Immunosuppressive Therapy for Angioimmunoblastic Lymphadenopathy with Dysproteinemia
| Autor: | Mario Cazzola, A. Castello, Laura Dezza, Edoardo Ascari, Gaetano Bergamaschi, Del Forno C, Umberto Magrini |
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| Rok vydání: | 1982 |
| Předmět: |
Cancer Research
Vincristine medicine.medical_specialty medicine.medical_treatment Antineoplastic Agents Procarbazine 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Prednisone Antineoplastic Combined Chemotherapy Protocols medicine Humans Mechlorethamine Sarcoma Kaposi Kaposi's sarcoma Immunodeficiency Aged Skin business.industry Combination chemotherapy Immunosuppression General Medicine medicine.disease Dermatology Oncology Immunoblastic Lymphadenopathy 030220 oncology & carcinogenesis Drug Therapy Combination Female Lymph Nodes Sarcoma business medicine.drug |
| Zdroj: | Tumori Journal. 68:537-542 |
| ISSN: | 2038-2529 0300-8916 |
| DOI: | 10.1177/030089168206800615 |
| Popis: | Cutaneous and visceral dissemination of Kaposi's sarcoma (KS) occurred in a patient with angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) who had been treated with combination chemotherapy. Three other cases of KS complicating immunosuppressive therapy of AILD have been reported in the literature, and there is evidence to indicate that AILD displays features which are known to predispose to KS. Like in other subjects with profound immunodeficiency (e.g. in young homosexual men), in our patient KS pursued an unusually aggressive course, with involvement of lymph nodes and internal organs as well as the skin. It is concluded that the risk of developing severe KS is a further reason to avoid aggressive combination chemotherapy in patients with AILD, particularly in those of Jewish or Mediterranean ancestry. Even the use of corticosteroids should be reduced to a minimum to avoid immunosuppression, and a conservative approach to treatment seems advisable. |
| Databáze: | OpenAIRE |
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