Tunable Upper Critical Solution Temperatures for Acrylamide Copolymers with Bile Acid Pendants
| Autor: | Qixuan Yu, Yong-Guang Jia, Meng Zhang, X. X. Zhu, Zhiyuan Ma |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Acrylamide
Aqueous solution Polymers and Plastics Comonomer beta-Cyclodextrins Bioengineering Chain transfer 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Bile Acids and Salts Biomaterials chemistry.chemical_compound chemistry Polymerization Dynamic light scattering Upper critical solution temperature Polymer chemistry Materials Chemistry Copolymer 0210 nano-technology |
| Zdroj: | Biomacromolecules. 18:2663-2668 |
| ISSN: | 1526-4602 1525-7797 |
| DOI: | 10.1021/acs.biomac.7b00860 |
| Popis: | Acrylamide derivatives of bile acids are chosen as a hydrophobic comonomer to copolymerize with acrylamide via reversible addition and fragmentation chain transfer (RAFT) polymerization to afford a series of copolymers of P(AAm-co-CAA). These copolymers exhibit a sharp and reversible insoluble–soluble transition in water upon heating to a mixing temperature (Tmix) related to the upper critical solution temperature (UCST). Tmix of these copolymers can be conveniently tuned to a practical temperature range, around 37 °C for biomedical applications. Tmix rises with increasing molar fraction of the bile acid-based acrylamide and increasing concentration of the aqueous solution of the copolymers. The addition of a natural host molecule β-cyclodextrin lowered the Tmix. The insoluble–soluble transition of the copolymers was also evidenced by dynamic light scattering and transmission electron microscopy. The biocompatible nature of the bile acids and β-cyclodextrins may make these copolymers potentially useful fo... |
| Databáze: | OpenAIRE |
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