Synthesis and characterization of a photo‐cross‐linked bioactive polycaprolactone‐based osteoconductive biocomposite
| Autor: | Seyyed Mostafa Fatemi, Alireza Moshaverinia, Farhood Najafi, Shahabi Sima, Fateme Razazpour |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Scaffold
Bone Regeneration Materials science Light Biocompatibility Polyesters Proton Magnetic Resonance Spectroscopy 0206 medical engineering Biomedical Engineering Biocompatible Materials 02 engineering and technology Bioceramic Polypropylenes Biomaterials chemistry.chemical_compound Fumarates Tissue engineering Apatites Elastic Modulus Materials Testing Spectroscopy Fourier Transform Infrared Humans Carbon-13 Magnetic Resonance Spectroscopy Fourier transform infrared spectroscopy Cell Death Metals and Alloys Spectrometry X-Ray Emission Biodegradation 021001 nanoscience & nanotechnology 020601 biomedical engineering Body Fluids Cross-Linking Reagents chemistry Chemical engineering Polycaprolactone Ceramics and Composites Biocomposite 0210 nano-technology Porosity |
| Zdroj: | Journal of Biomedical Materials Research Part A. 109:1858-1868 |
| ISSN: | 1552-4965 1549-3296 |
| DOI: | 10.1002/jbm.a.37178 |
| Popis: | In this study, a light cross-linkable biocomposite scaffold based on a photo-cross-linkable poly (propylene fumarate) (PPF)-co-polycaprolactone (PCL) tri-block copolymer was synthesized and characterized. The developed biodegradable scaffold was further modified with β-tricalcium phosphate (β-TCP) bioceramic for bone tissue engineering applications. The developed biocomposite was characterized using H nuclear magnetic resonance and Fourier transform infrared spectroscopy. Moreover, the bioceramic particle size distribution and morphology were evaluated using Brunauer-Emmett-Teller method, X-ray diffraction, and scanning electron microscopy. The mechanical properties and biodegradation of the scaffolds were also evaluated. Cytotoxicity and mineralization assays were performed to analyze the biocompatibility and bioactivity capacity of the developed biocomposite. The characterization data confirmed the development of a biodegradable and photo-cross-linkable PCL-based biocomposite reinforced with β-TCP bioceramic. In vitro analyses demonstrated the biocompatibility and mineralization potential of the synthesized bioceramic. Altogether, the results of the present study suggest that the photo-cross-linkable PCL-PPF-PCL tri-block copolymer reinforced with β-TCP is a promising biocomposite for bone tissue engineering applications. According to the results, this newly synthesized material has a proper chemical composition for further clinically-relevant studies in tissue engineering. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text