Further Evidence for Amyloid Deposition in Clinical Pancreatic Islet Grafts
| Autor: | Franco Folli, Per Westermark, Tatsuya Kin, Arne Andersson, A. M. James Shapiro, Alberto M. Davalli, Gunnar Tufveson, Gunilla T. Westermark, Antonio Secchi, Olle Korsgren, Christian Toso |
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| Přispěvatelé: | Gunilla T., Westermark, Alberto M., Davalli, Secchi, Antonio, Franco, Folli, Tatsuya, Kin, Christian, Toso, A. M., James Shapiro, Olle, Korsgren, Gunnar, Tufveson, Arne, Andersson, Per, Westermark |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology endocrine system Amyloid endocrine system diseases Islets of Langerhans Transplantation Article Islets of Langerhans Fatal Outcome Internal medicine Partial loss Proprotein Convertase 2/metabolism medicine Humans Islets of Langerhans/metabolism/pathology Transplantation Type 1 diabetes geography geography.geographical_feature_category Liver/metabolism/pathology ddc:617 business.industry Islets of Langerhans Transplantation/adverse effects/mortality/pathology/physiology Islet Amyloid Polypeptide/metabolism Middle Aged medicine.disease Islet Immunohistochemistry Tissue Donors Islet Amyloid Polypeptide Allogeneic graft Endocrinology Amyloid deposition surgical procedures operative Diabetes Mellitus Type 1 Proprotein Convertase 2 Liver Diabetes Mellitus Type 1/surgery Female Beta cell business |
| Zdroj: | Transplantation, Vol. 93, No 2 (2012) pp. 219-23 |
| ISSN: | 0041-1337 |
| Popis: | Background. The reasons for the long-term complete or partial loss of islet graft function are unknown, but there areobviously other reasons than just pure allogeneic graft rejection. Earlier studies have shown that deposition of isletamyloid polypeptide amyloid in transplanted islets may indicate a mechanism for loss of cells.Materials and Methods. Sections from liver material from four deceased islet-bearing recipients have been scrutinizedfor the presence of amyloid. Clinical data and certain aspects of the islet graft pathology of these patients have beenpublished previously.Result. With this extended histological analysis, we demonstrate the occurrence of amyloid deposits in islets transplantedinto the liver in three of four patients with type 1 diabetes.Conclusion. The finding adds evidence to the assumption that aggregation of islet amyloid polypeptide might be animportant cause of progressing -cell dysfunction in clinically transplanted islets. |
| Databáze: | OpenAIRE |
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