Scorpion (Buthus tamulus) venom toxicity on cardiopulmonary reflexes involves kinins via 5-HT3 receptor subtypes
| Autor: | S. Bagchi, S. B. Deshpande |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
aprotinin
Bradycardia Bradykinin Venom Pharmacology Toxicology complex mixtures Buthus tamulus kinins 5-HT3 receptor Ondansetron chemistry.chemical_compound medicine Aprotinin indian red scorpion biology business.industry cardiopulmonary reflexes 5-HT3 receptors chemistry ondansetron Anesthesia Toxicity Bezold-Jarisch reflex Reflex biology.protein bradykinin medicine.symptom business medicine.drug |
| Zdroj: | Journal of Venomous Animals and Toxins, Volume: 7, Issue: 1, Pages: 25-44, Published: 2001 |
| ISSN: | 0104-7930 |
| DOI: | 10.1590/s0104-79302001000100003 |
| Popis: | The mechanisms underlying the action of Indian red scorpion Buthus tamulus (BT) venom-induced augmentation of cardiopulmonary reflexes elicited by intravenous injection of 5-HT were examined in urethane anaesthetized rats. The 5-HT produced a concentration-dependent increase in time-response area of bradycardiac response, with the responses at submaximal concentrations shifted to the left after exposure to BT venom (20 µg/kg, IV). Aprotinin (6000 kallikrein inactivating unit, IV) as such had no effect on 5-HT reflex responses (bradycardia, hypotension, and apnea), but blocked the venom-induced reflex augmentation. While ondansetron (10 µg/kg, IV) completely blocked the 5-HT reflex responses, these reappeared partially after venom exposure (20 µg/kg). Exposure to bradykinin (50 µg/kg, IV) for 30 min also augmented the 5-HT-induced reflex responses similar to venom. The bradykinin-induced augmentation was also blocked by ondansetron. Results indicate that the venom-induced augmentation of cardiopulmonary reflexes is mediated through kinins sensitizing 5-HT3 receptor subtypes. |
| Databáze: | OpenAIRE |
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