Cyclosporin A ameliorates eclampsia seizure through reducing systemic inflammation in an eclampsia-like rat model
Autor: | Bihui Hu, Xiaodan Di, Qian Huang, Huishu Liu, Junjie Bao, Jinying Yang, Xinjia Han |
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Rok vydání: | 2019 |
Předmět: |
medicine.medical_specialty
Physiology medicine.medical_treatment Intraperitoneal injection Blood Pressure 030204 cardiovascular system & hematology Systemic inflammation Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Pregnancy Seizures Cyclosporin a Internal medicine Internal Medicine medicine Animals Eclampsia 030212 general & internal medicine Pentylenetetrazol reproductive and urinary physiology Inflammation Seizure threshold business.industry medicine.disease female genital diseases and pregnancy complications Rats Disease Models Animal Blood pressure Endocrinology embryonic structures Cyclosporine Cytokines Female medicine.symptom Cardiology and Cardiovascular Medicine business Immunosuppressive Agents medicine.drug |
Zdroj: | Hypertension research : official journal of the Japanese Society of Hypertension. 43(4) |
ISSN: | 1348-4214 |
Popis: | Our previous studies have shown that the maternal hyperinflammatory response in pre-eclampsia lowered the eclampsia-like seizure threshold. Cyclosporin A (CsA), which is an effective immunosuppressant, could attenuate the inflammatory responses in LPS-induced pre-eclampsia rats. Here, we hypothesized that CsA may ameliorate seizure severity through reducing systemic inflammation in pre-eclampsia/eclampsia. In the current study, the effects of CsA on pre-eclampsia manifestation, eclampsia-like seizure activities and systemic inflammation were examined in a pre-eclampsia model. Pregnant rats were given an intraperitoneal injection of the epileptogenic drug pentylenetetrazol (PTZ) following a tail vein injection of lipopolysaccharide to establish the eclampsia-like seizure model. CsA (5 mg/kg) was administered intravenously through the tail after LPS infusion. Mean systolic blood pressure and proteinuria in pre-eclampsia were detected. After PTZ injection, seizure activity was assessed, inflammatory responses were determined and pregnancy outcomes were analyzed. The results showed that CsA treatment significantly decreased blood pressure and proteinuria and increased the fetal and placental weight (P |
Databáze: | OpenAIRE |
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