Ocean Dwelling Actinobacteria as Source of Antitumor Compounds
| Autor: | Kodiveri Muthukaliannan Gothandam, Ajitha Gomathi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Antifungal medicine.drug_class lcsh:Biotechnology Secondary metabolite complex mixtures Bottle neck Actinobacteria 03 medical and health sciences chemistry.chemical_compound lcsh:TP248.13-248.65 medicine Bioprospecting Multidisciplinary Natural product biology Drug discovery business.industry biology.organism_classification Bioactive compound Biotechnology antitumor compounds 030104 developmental biology chemistry bioactivity Marine actinobacteria bacteria business medicine.drug |
| Zdroj: | Brazilian Archives of Biology and Technology, Vol 59, Iss 0 (2016) Brazilian Archives of Biology and Technology v.59 2016 Brazilian Archives of Biology and Technology Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR Brazilian Archives of Biology and Technology, Volume: 59, Article number: e16160055, Published: 01 AUG 2016 |
| ISSN: | 1516-8913 |
| Popis: | Extending over decades, research has been of great focus and enormous progress on exploring the ocean for natural products from marine actinobacteria. Attraction towards alternative medicine has led to improvements in natural product discovery. With great potential to survive in extreme environments, marine actinobacteria, efficiently produce an array of metabolites with diverse bioactivity by evolving the secondary metabolic pathways. Exploiting the secondary metabolite producing potential of actinobacteria, many compounds with antitumor, antibacterial, antifungal, antimalarial, antiprotozoal, antiparasitic, antiviral, anti-parasitic, anti-inflammatory activities has been discovered. Efforts in bioprospecting alternative sources of natural products have thus led to several explorations and improvements in technologies which has decreased the bottle neck difficulties in the drug discovery process. Emphasizing on the recent advancements in bioactive compound production in actinobacteria, this paper comprises a review of the available literature, compiles the antitumor compounds from marine actinobacteria with brief discussions and the perspectives to develop better antitumor compounds which would stimulate further research. |
| Databáze: | OpenAIRE |
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