Neurodevelopment in Schizophrenia: The Role of the Wnt Pathways
| Autor: | Paolo Girardi, Emanuela Danese, Giorgio D. Kotzalidis, Delfina Janiri, Lavinia De Chiara, Valeria Savoja, Daniele Serata, Ilaria Cuomo, Giovanni Manfredi, Chiara Brugnoli, Marta Motolese, Federica Caccia, Elisa Ambrosi, Ferdinando Nicoletti, Chiara Rapinesi, Alberto Forte, Isabella Panaccione, Gabriele Sani, Flavia Napoletano, Antonio Del Casale, Alessio Simonetti |
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| Rok vydání: | 2013 |
| Předmět: |
Wingless (Wnt) signalling
medicine.medical_treatment Neurodevelopment Epigenetics of schizophrenia Article 03 medical and health sciences 0302 clinical medicine mental disorders Medicine Pharmacology (medical) Antipsychotic drug Antipsychotic 030304 developmental biology Pharmacology 0303 health sciences antipsychotic drugs neurodevelopment schizophrenia wingless (wnt) signalling business.industry Mechanism (biology) Wnt signaling pathway General Medicine medicine.disease 3. Good health Psychiatry and Mental health Neurology Schizophrenia Antipsychotic Drugs Neurology (clinical) business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Current Neuropharmacology |
| ISSN: | 1570-159X |
| DOI: | 10.2174/1570159x113119990037 |
| Popis: | Objectives. To review the role of Wnt pathways in the neurodevelopment of schizophrenia. Methods: Systematic PubMed search, using as keywords all the terms related to the Wnt pathways and crossing them with each of the following areas: normal neurodevelopment and physiology, neurodevelopmental theory of schizophrenia, schizophrenia, and antipsychotic drug action. Results: Neurodevelopmental, behavioural, genetic, and psychopharmacological data point to the possible involvement of Wnt systems, especially the canonical pathway, in the pathophysiology of schizophrenia and in the mechanism of antipsychotic drug action. The molecules most consistently found to be associated with abnormalities or in antipsychotic drug action are Akt1, glycogen synthase kinase3beta, and beta-catenin. However, the extent to which they contribute to the pathophysiology of schizophrenia or to antipsychotic action remains to be established. Conclusions: The study of the involvement of Wnt pathway abnormalities in schizophrenia may help in understanding this multifaceted clinical entity; the development of Wnt-related pharmacological targets must await the collection of more data. |
| Databáze: | OpenAIRE |
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