Deletion of nef slows but does not prevent CD4-positive T-cell depletion in human immunodeficiency virus type 1-infected human-PBL-SCID mice
| Autor: | Richard J. Gulizia, D Trono, Ronald G. Collman, Donald E. Mosier, Jay A. Levy |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
CD4-Positive T-Lymphocytes
viruses Immunology Human immunodeficiency virus (HIV) Viremia Mice SCID Scid mice Biology medicine.disease_cause Microbiology Virus Mice Animal model Virology Leukocytes medicine Animals Humans Gene Acquired Immunodeficiency Syndrome virus diseases T-cell depletion medicine.disease Pathogenicity Genes nef Insect Science HIV-1 RNA Viral Gene Deletion Research Article |
| Zdroj: | Journal of Virology. 71:4161-4164 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.71.5.4161-4164.1997 |
| Popis: | The pathogenicity of four human immunodeficiency virus type 1 (HIV-1) isolates with nef deleted for SCID mice repopulated with human peripheral blood leukocytes (hu-PBL-SCID mice) was studied. Deletion of nef led to a substantial reduction in CD4-positive T-cell depletion and delayed kinetics of plasma viremia in infected hu-PBL-SCID mice. Deletion of the nef gene impacts both the efficiency of primary infection and the cytopathicity of virus for infected CD4-positive T cells in this animal model of HIV-1 infection. |
| Databáze: | OpenAIRE |
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