Cytokine-enhanced vaccine and interferon-β plus suicide gene as combined therapy for spontaneous canine sarcomas
| Autor: | María L. Gil-Cardeza, Liliana M.E. Finocchiaro, Marcela Solange Villaverde, Gerardo Claudio Glikin, María D. Riveros |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Ganciclovir Pathology medicine.medical_specialty medicine.medical_treatment Apoptosis Cancer Vaccines Thymidine Kinase Subcutaneous injection Dogs medicine Animals Simplexvirus Dog Diseases General Veterinary business.industry Soft tissue sarcoma Granulocyte-Macrophage Colony-Stimulating Factor Sarcoma Genetic Therapy Interferon-beta Suicide gene medicine.disease Combined Modality Therapy Treatment Outcome Cytokine Cancer research Cytokines Interleukin-2 Osteosarcoma Female Lymph business Adjuvant medicine.drug |
| Zdroj: | Research in Veterinary Science. 91:230-234 |
| ISSN: | 0034-5288 |
| Popis: | Eleven soft tissue- and five osteosarcoma canine patients were subjected to: (i) periodic subcutaneous injection of irradiated xenogeneic cells secreting hGM-CSF and hIL-2 mixed with allogeneic or autologous tumor homogenates; and (ii) injections of cIFN-β and HSVtk-carrying lipoplexes and ganciclovir, marginal (after surgery) and/or intratumoral (in the case of partial tumor resection, local relapse or small surface tumors). This treatment alone (4 patients) or as surgery adjuvant (12 patients), was safe and well tolerated. In those patients presenting local disease (6/11), the suicide gene plus cIFN-β treatment induced local antitumor activity evidenced by the objective responses (3 complete, 2 partial) and stable diseases (2). In addition, the treatment prevented or delayed local relapse, regional metastases (lymph nodes developed only in 3/16) and distant metastases (0/16), suggesting a strong systemic antitumor immunity. The most encouraging result was the long survival times of 10 patients (>1 year, with good quality of life). |
| Databáze: | OpenAIRE |
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