Expression and intracellular localization of heat shock proteins in multidrug resistance of a cisplatin resistant human ovarian cancer cell line
| Autor: | Toshimitsu Suzuki, Tomoko Kamishima, Yoshiya N, Takeaki Fukuda |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Cancer Research
medicine.medical_specialty Hot Temperature Drug resistance Biology Internal medicine Heat shock protein medicine Tumor Cells Cultured Humans Doxorubicin Etoposide Heat-Shock Proteins Cisplatin Ovarian Neoplasms Drug Resistance Multiple Multiple drug resistance Endocrinology DNA Topoisomerases Type II Oncology Cell culture Cancer research Female Intracellular medicine.drug |
| Zdroj: | Cancer letters. 116(2) |
| ISSN: | 0304-3835 |
| Popis: | TYK-R10 is a cisplatin resistant human ovarian carcinoma cell line and showed a cross resistance to various anti-cancer drugs including adriamycin (ADR), vincristine (VCR) and etoposide, despite a lack of multidrug phenotype. Under normal conditions, various heat shock proteins (HSPs) were expressed in TYK-R10 but not in parental line (TYK-nu). Non-lethal short-term heat shock treatment induced a high tolerance for cisplatin and VCR in TYK-R10 and ADR, and VCR in TYK-nu. This treatment induced and/or enhanced the expression of various types of HSPs in various intracellular localizations in both TYK-R10 and TYK-nu, with minor differences. These findings indicate that combined expression and intracellular localization of HSPs may play an important role in drug resistance of TYK-R10. |
| Databáze: | OpenAIRE |
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