A long-term follow-up study in essential cryoglobulinemia
| Autor: | P. Borzini, Fulvio Invernizzi, Carlo Zanussi, R. Cattaneo, Pietro Pioltelli, G. Mont, V. Gavazzeni |
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| Rok vydání: | 1979 |
| Předmět: |
Adult
Liver Cirrhosis Male Adolescent Long term follow up Paraproteinemias Essential cryoglobulinemia Antibodies Glomerulonephritis hemic and lymphatic diseases Medicine Humans Cryoglobulins Aged Autoantibodies business.industry Hematology General Medicine Complement System Proteins DNA Middle Aged medicine.disease Cryoglobulinemia Lymphoproliferative Disorders Complement (complexity) Immunology Kidney Failure Chronic Female Lymphoproliferative disease Waldenstrom Macroglobulinemia business Follow-Up Studies |
| Zdroj: | Acta haematologica. 61(2) |
| ISSN: | 0001-5792 |
| Popis: | In a case series of 56 patients with essential cryoglobulinemia, 35 were followed-up for 4-13 years (mean 7 years). A membranous proliferative glomerulonephritis, which in about half the cases showed a progression to renal insufficiency, was the commonest complication, observed in more than one third of the patients. In 2 patients hepatic cirrhosis became manifest after a completely asymptomatic period and in 2 others a lymphoproliferative disease appeared 2 and 8 years after the onset of purpura. In 51% of patients the intial clinical pattern did not change. In searching for a correlation between the development of nephropathy and cryoglobulin characteristics, none was demonstrated studying the cryoglobulin level, the presence of autoantibody and the complement components. |
| Databáze: | OpenAIRE |
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