Marine Origin Polysaccharides in Drug Delivery Systems

Autor: Matias J. Cardoso, João F. Mano, Rui R. Costa
Přispěvatelé: Universidade do Minho
Jazyk: angličtina
Předmět:
0301 basic medicine
Aquatic Organisms
Polysaccharides
marine excipients
Biocompatibility
Chemistry
Pharmaceutical
Oceans and Seas
Pharmaceutical Science
Nanotechnology
02 engineering and technology
Review
Regenerative Medicine
Chitosan
Biomaterials
03 medical and health sciences
chemistry.chemical_compound
Drug Delivery Systems
Drug Discovery
Marine excipients
Animals
Humans
14. Life underwater
Pharmacology
Toxicology and Pharmaceutics (miscellaneous)
lcsh:QH301-705.5
Drug Carriers
Science & Technology
Gene Transfer Techniques
Biodegradation
Polysaccharide/drug conjugates
021001 nanoscience & nanotechnology
Controlled release
Carrageenan
Ppolysaccharide/drug conjugates
030104 developmental biology
chemistry
lcsh:Biology (General)
13. Climate action
Delayed-Action Preparations
Drug Design
polysaccharide
Self-healing hydrogels
Drug delivery
drug conjugates
0210 nano-technology
Drug carrier
Zdroj: Marine Drugs
Marine Drugs, Vol 14, Iss 2, p 34 (2016)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
ISSN: 1660-3397
2014-6698
DOI: 10.3390/md14020034
Popis: Oceans are a vast source of natural substances. In them, we find various compounds with wide biotechnological and biomedical applicabilities. The exploitation of the sea as a renewable source of biocompounds can have a positive impact on the development of new systems and devices for biomedical applications. Marine polysaccharides are among the most abundant materials in the seas, which contributes to a decrease of the extraction costs, besides their solubility behavior in aqueous solvents and extraction media, and their interaction with other biocompounds. Polysaccharides such as alginate, carrageenan and fucoidan can be extracted from algae, whereas chitosan and hyaluronan can be obtained from animal sources. Most marine polysaccharides have important biological properties such as biocompatibility, biodegradability, and anti-inflammatory activity, as well as adhesive and antimicrobial actions. Moreover, they can be modified in order to allow processing them into various shapes and sizes and may exhibit response dependence to external stimuli, such as pH and temperature. Due to these properties, these biomaterials have been studied as raw material for the construction of carrier devices for drugs, including particles, capsules and hydrogels. The devices are designed to achieve a controlled release of therapeutic agents in an attempt to fight against serious diseases, and to be used in advanced therapies, such as gene delivery or regenerative medicine.
This work was supported by Fundação para a Ciência e Tecnologia (FCT, Grant SFRH/BPD/95446/2013), “Fundo Social Europeu” (FSE), “Programa Operacional de Potencial Humano” (POPH), and by European Research Council grant agreement ERC-ADG-2014-669858 for project ATLAS.
Databáze: OpenAIRE
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