Synaptic Vesicle Protein 2 and Vesicular Monoamine Transporter 1 and 2 Are Expressed in Neuroblastoma

Autor: Apostolos V. Tsolakis, Rolf Christofferson, Eva Tiensuu Janson, Kleopatra Georgantzi, Lars Grimelius, Åke M. Jakobson
Rok vydání: 2019
Předmět:
Male
Endocrinology
Diabetes and Metabolism
markers
Vesicular monoamine transporter 1
Pediatrics
Neuroblastoma
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Child
urine-dopamine
Membrane Glycoproteins
Chemistry
urine-HVA
Pediatrik
General Medicine
Prognosis
Immunohistochemistry
Cell biology
Treatment Outcome
Child
Preschool
030220 oncology & carcinogenesis
immunohistochemistry
Female
Antineoplastic Agents
Nerve Tissue Proteins
030209 endocrinology & metabolism
Synaptic vesicle
Pathology and Forensic Medicine
neuroblastoma
03 medical and health sciences
Stomach Neoplasms
Biomarkers
Tumor
medicine
neuroendocrine
Humans
neoplasms
urine-VMA
Cancer och onkologi
Kirurgi
Infant
Newborn
Infant
medicine.disease
nervous system
Cancer and Oncology
Case-Control Studies
Vesicular Monoamine Transport Proteins
Surgery
Zdroj: Endocrine Pathology. 30:173-179
ISSN: 1559-0097
1046-3976
Popis: Neuroblastoma (NB), the most common extracranial cancer in childhood, exhibits neuroendocrine (NE) differentiation. Two well-established NE markers, chromogranin A (CgA) and synaptophysin (syn), are used in the histopathological diagnostics. Our aims were to explore if the NE markers synaptic vesicle protein 2 (SV2) and vesicular monoamine transporter 1 (VMAT1) and 2 (VMAT2) also are expressed in human NB and if so, evaluate their usefulness in NB histopathological diagnostics. Tumor specimens from 21 NB patients, before and/or after chemotherapy, were immunostained for CgA, syn, SV2, VMAT1, and VMAT2. Clinical data was extracted from patients' records. SV2 was highly expressed in NB, as was CgA while syn was less frequently expressed compared to the other two. Both VMATs were expressed in several NB, VMAT2 in more cases than VMAT1 and its expression was similar to syn. Chemotherapy did not affect the immunoreactivity in an obvious way. SV2 was highly expressed in NB and can thus be useful marker in NB diagnostics. VMAT1 and VMAT2 were also expressed in NB but similar to syn less reliable as tumor markers.
Databáze: OpenAIRE
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