Metabolomics analysis of oral mucosa reveals profile perturbation in reticular oral lichen planus
| Autor: | Shuai-nan Zhang, Xu-zhao Li, Xu-yan Yang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Clinical Biochemistry Disease medicine.disease_cause Biochemistry Mass Spectrometry Pathogenesis Young Adult 03 medical and health sciences 0302 clinical medicine Metabolomics medicine Humans Oral mucosa Pathological business.industry Biochemistry (medical) Mouth Mucosa 030206 dentistry General Medicine Middle Aged medicine.disease stomatognathic diseases medicine.anatomical_structure 030220 oncology & carcinogenesis Reticular connective tissue Female Oral lichen planus business Software Oxidative stress Chromatography Liquid Lichen Planus Oral |
| Zdroj: | Clinica Chimica Acta. 487:28-32 |
| ISSN: | 0009-8981 |
| Popis: | Background Oral lichen planus (OLP) is a chronic inflammatory mucosal disorder and potentially oral premalignant lesion affecting the stratified squamous epithelia. In OLP, reticular type is the most common clinical form of the disease. However, little is known about it. Metabolomics analysis may help to investigate the disease pathogenesis and to improve clinical treatment. Methods Liquid chromatography (LC)-mass spectrometry (MS) system, XCMS software, SIMCA software, and OSI / SMMS software were integrated to identify differentially expressed metabolites for the pathways and pathology analysis. Results Totally, 21 modulated metabolites were identified, whose dysregulations affected 30 metabolic pathways. Through an impact-value screen (impact-value>0.1), 8 pathways were selected as the significantly dysregulated pathways. Pathological network showed that these metabolites participated in 5 pathological processes, that is, inflammatory lesion, DNA damage and repair disorder, apoptosis process, oxidative stress injury, and abnormal energy expenditure. Conclusion The study revealed the metabolic perturbation of oral mucosa in reticular OLP, which may provide an important reference for the understanding of the pathogenesis of the disease and the discovery of therapeutic targets. |
| Databáze: | OpenAIRE |
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