Characterization of Solid Lipid Nanoparticles Containing Caffeic Acid and Determination of its Effects on MCF-7 Cells
| Autor: | Gamze Guney, Gökhan Dikmen, Lütfi Genç |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Cancer Research
Antioxidant Chemistry Pharmaceutical Drug Compounding medicine.medical_treatment Nanoparticle Antineoplastic Agents Breast Neoplasms Patents as Topic chemistry.chemical_compound Caffeic Acids Drug Delivery Systems Spectroscopy Fourier Transform Infrared Drug Discovery Solid lipid nanoparticle Zeta potential medicine Caffeic acid Humans Organic chemistry Pharmacology (medical) Particle Size chemistry.chemical_classification Drug Carriers Chromatography Chemistry food and beverages General Medicine Hydroxycinnamic acid Lipids Oncology Delayed-Action Preparations MCF-7 Cells Microscopy Electron Scanning Nanoparticles Female Drug carrier Homogenization (biology) |
| Zdroj: | Recent Patents on Anti-Cancer Drug Discovery. 10:224-232 |
| ISSN: | 1574-8928 |
| DOI: | 10.2174/1574892810666150115124413 |
| Popis: | Many anticancer drugs that are currently used in cancer treatment are natural products or their analogues by structural modification. Caffeic acid (3, 4-dihydroxycinnamic acid; CA) is classified as hydroxycinnamic acid and has a variety of potential pharmacological effects, including antioxidant, immunomodulatory and anti-inflammatory activities. As a drug carrier, solid lipid nanoparticles (SLNs) introduced to improve stability, provide controlled drug release, avoid organic solvents and are obtained in small sizes. In this study, we developed solid lipid nanoparticles incorporating with caffeic acid using hot homogenization method. Caffeic acid loaded solid lipid nanoparticles were characterized regarding particle size, zeta potential, drug entrapment efficiency, drug release, scanning electron microscopy (SEM) and FT-IR. The effects of caffeic acid loaded solid lipid nanoparticles on MCF-7 cells were determined by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-dimethyl tetrazolium bromide (MTT) test and Annexin V-PI analysis. As a result, solid lipid nanoparticles could potentially be used for the delivery of caffeic acid and solid lipid nanoparticles formulation enhanced the effects of caffeic acid on MCF-7 cells. Some relevant patents are also referred in this article. |
| Databáze: | OpenAIRE |
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