Ductal lavage findings in women with mammographic microcalcifications undergoing biopsy
| Autor: | Stephanie Benjamin, Monica Morrow, Judy A. Wolfman, Lewis Segal, Ritu Nayar, Michele Bryk, Seema A. Khan, Elizabeth L. Wiley |
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| Rok vydání: | 2004 |
| Předmět: |
Pathology
medicine.medical_specialty Bodily Secretions Ductal lavage medicine.medical_treatment Biopsy Cytological Techniques Breast Neoplasms Atypical hyperplasia Breast Diseases Breast cancer medicine Mammography Humans Prospective Studies skin and connective tissue diseases Mammary Glands Human Therapeutic Irrigation medicine.diagnostic_test business.industry Calcinosis Hyperplasia Middle Aged medicine.disease Oncology Surgery Female Radiology Ductography business Mastectomy |
| Zdroj: | Annals of surgical oncology. 12(9) |
| ISSN: | 1068-9265 |
| Popis: | We designed a prospective study to assess the likelihood that early lesions presenting as mammographic calcifications could be accessed for cytological diagnosis by ductal lavage (DL). Consenting women with calcifications (Breast Imaging Reporting and Data System 4 or 5) underwent DL of fluid-yielding ducts (FYDs) before stereotactic core or excisional biopsy. The DL catheter was used to inject .2 to 1 mL of Isovue 300 into the duct to determine whether the FYD corresponded to the duct containing calcifications (designated overlap). Additional FYDs were injected, if possible, until overlap was identified. DL cytology was compared with histology. Twenty women were enrolled (mean age, 54.2 years); the mean size of the calcification-bearing area was 190 mm2. The histological findings were as follows: 1 invasive cancer, 9 ductal carcinomas-in-situ (DCIS), 5 atypical hyperplasias, and 5 usual hyperplasias or fibrocystic changes. Four women had no FYD. In 15 women who underwent DL and ductography, overlap of dye and calcifications was seen in 4 (27%): 1 fibrocystic change, 1 hyperplasia, 1 atypical hyperplasia (cytological diagnosis mildly atypical), and 1 DCIS (cytological diagnosis benign). Of the remaining 8 DCIS lesions, 4 had no nipple aspiration fluid, 1 showed extravasation, and 3 were lavaged but the duct did not overlap. These results are consistent with data from women undergoing mastectomy for larger invasive cancer and DCIS and show that cancer-containing ducts do not yield nipple fluid in most cases. |
| Databáze: | OpenAIRE |
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