'On-' and 'off-' cells in the rostral ventromedial medulla of rats held in thermoneutral conditions: are they involved in thermoregulation?
| Autor: | Bernard Pollin, Nabil El Bitar, Daniel Le Bars |
|---|---|
| Přispěvatelé: | Physiopathologie des maladies psychiatriques = Pathophysiology of Psychiatric Disorders (NPS-07), Neurosciences Paris Seine (NPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Societe Francaise d'Etude et de Traitement de la Douleur (SFETD) et l'Institut UPSA de la Douleur (IUD), Neuroscience Paris Seine (NPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Sympathetic Nervous System pain modulation Physiology Blood Pressure Vasomotion Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Heart Rate Internal medicine Heart rate medicine Animals 030304 developmental biology Neurons Pain modulation Medulla Oblongata thermoregulation 0303 health sciences Core (anatomy) Chemistry General Neuroscience Thermoregulation Rats Vasomotor System Endocrinology Blood pressure rostral medullary raphe [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] blood pressure variability Rostral ventromedial medulla rostral ventromedial medulla 030217 neurology & neurosurgery Body Temperature Regulation |
| Zdroj: | Journal of Neurophysiology Journal of Neurophysiology, American Physiological Society, 2014, 112 (9), pp.2199-2217. ⟨10.1152/jn.00722.2013⟩ Journal of Neurophysiology, 2014, 112 (9), pp.2199-2217. ⟨10.1152/jn.00722.2013⟩ |
| ISSN: | 1522-1598 0022-3077 |
| DOI: | 10.1152/jn.00722.2013 |
| Popis: | International audience; In thermal neutral condition, rats display cyclic variations of the vasomotion of the tail and paws, synchronized with fluctuations of blood pressure, heart rate, and core body temperature. ``On-'' and ``off-'' cells located in the rostral ventromedial medulla, a cerebral structure implicated in somatic sympathetic drive, 1) exhibit similar spontaneous cyclic activities in antiphase and 2) are activated and inhibited by thermal nociceptive stimuli, respectively. We aimed at evaluating the implication of such neurons in autonomic regulation by establishing correlations between their firing and blood pressure, heart rate, and skin and core body temperature variations. When, during a cycle, a relative high core body temperature was reached, the on-cells were activated and within half a minute, the off-cells and blood pressure were depressed, followed by heart rate depression within a further minute; vasodilatation of the tail followed invariably within similar to 3 min, often completed with vasodilatation of hind paws. The outcome was an increased heat loss that lessened the core body temperature. When the decrease of core body temperature achieved a few tenths of degrees, sympathetic activation switches off and converse variations occurred, providing cycles of three to seven periods/h. On- and off-cell activities were correlated with inhibition and activation of the sympathetic system, respectively. The temporal sequence of events was as follows: core body temperature -> on-cell -> off-cell -> blood pressure -> heart rate -> skin temperature -> core body temperature. The function of on- and off-cells in nociception should be reexamined, taking into account their correlation with autonomic regulations. |
| Databáze: | OpenAIRE |
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