Distinct Temporal Expression of 5-HT1A and 5-HT2A Receptors on Cerebellar Granule Cells in Mice
| Autor: | Marlies Oostland, M. Renate Buijink, Johannes A. van Hooft, Lars von Oerthel, Marten P. Smidt, Guus M. Teunisse |
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| Přispěvatelé: | Cellular and Computational Neuroscience (SILS, FNWI), Molecular Neuroscience (SILS, FNWI) |
| Rok vydání: | 2014 |
| Předmět: |
Male
Serotonin receptors Cerebellum Patch-Clamp Techniques Receptor expression Action Potentials In Vitro Techniques Biology Synaptic plasticity Mice Serotonin Agents medicine Animals Receptor Serotonin 5-HT2A Receptor Long-term depression 5-HT receptor Medicine(all) 6-Cyano-7-nitroquinoxaline-2 3-dione Neurons Original Paper Age Factors Excitatory Postsynaptic Potentials Gene Expression Regulation Developmental Electric Stimulation Mice Inbred C57BL medicine.anatomical_structure CXCL3 Animals Newborn nervous system Neurology Receptor Serotonin 5-HT1A Female Neurology (clinical) Serotonin Excitatory Amino Acid Antagonists Neuroscience |
| Zdroj: | The Cerebellum, 13(4), 491-500. Springer New York Cerebellum (London, England) |
| ISSN: | 1473-4230 1473-4222 |
| Popis: | Serotonin plays an important role of controlling the physiology of the cerebellum. However, serotonin receptor expression has not been fully studied in the developing cerebellum. We have recently shown that cerebellar granule cells transiently express 5-HT3 receptors. In the present study, we investigate expression of 5-HT1 and 5-HT2 receptors in the mouse cerebellum both during postnatal development and in juvenile mice. Here, we show for the first time that 5-HT1A and 5-HT2A receptors are present on cerebellar granule cells with a distinct temporal expression pattern: 5-HT1A receptors are expressed only during the first 2 weeks, while 5-HT2A receptor expression persists until at least 8 weeks after birth. Because of its prolonged expression pattern, we investigated the electrophysiological properties of the 5-HT2A receptor. 5-HT2A receptors expressed by cerebellar granule cells promote stability by reducing variability of the synaptic response, and they modulate the paired-pulse ratio of the parallel fibre-Purkinje cell synapse. Furthermore, pharmacological block of 5-HT2A receptors enhances short-term synaptic plasticity at the parallel fibre-Purkinje cell synapse. We thus show a novel role for serotonin in controlling function of the cerebellum via 5-HT2A receptors expressed by cerebellar granule cells. |
| Databáze: | OpenAIRE |
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