Distribution of peripheral lymphocytes in Alzheimer patients and controls
| Autor: | Maurice W Dysken, Trey Sunderland, Stacy Skare, Marcia D. Minichiello, John T. Little, James L. Hill, Susan E. Molchan |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Hydrocortisone Lymphocyte Pathogenesis Leukocyte Count Degenerative disease Immune system Alzheimer Disease mental disorders medicine Humans Distribution (pharmacology) Dementia Lymphocytes Biological Psychiatry Aged Aged 80 and over business.industry Middle Aged medicine.disease Peripheral Psychiatry and Mental health medicine.anatomical_structure Immunology Female Alzheimer's disease Mental Status Schedule business |
| Zdroj: | Journal of Psychiatric Research. 26:213-218 |
| ISSN: | 0022-3956 |
| DOI: | 10.1016/0022-3956(92)90024-i |
| Popis: | Deficient immunoregulation has been postulated to play a role in the pathogenesis of Alzheimer's dementia. Recently, lymphopenia was reported to be more prevalent in Alzheimer patients than in control subjects. In addition, a decreasing number of total lymphocytes was found to be significantly correlated with increasing severity of dementia. In an attempt to replicate these findings, we studied 55 Alzheimer patients and 41 healthy controls of comparable age and gender, but found no significant difference in the distribution of total lymphocytes between these groups. Furthermore, total lymphocytes were not significantly correlated with dementia severity. Our findings, therefore, do not lend further support to an immune hypothesis for Alzheimer's dementia. |
| Databáze: | OpenAIRE |
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