The influence of thermal trauma on pro- and anticoagulant activity of erythrocyte-derived microvesicles
| Autor: | Ekaterina Sukhareva, Grigory Levin |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Erythrocytes Adolescent Thermal trauma 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine Anticoagulant activity Antithrombins Young Adult 03 medical and health sciences 0302 clinical medicine Cell-Derived Microparticles Internal medicine medicine Humans Blood Coagulation Aged medicine.diagnostic_test Coagulants business.industry Antithrombin Anticoagulants 030208 emergency & critical care medicine Antithrombin Activity General Medicine Middle Aged Blood coagulation factors Blood Coagulation Factors Thromboelastography Microvesicles Thrombelastography Endocrinology Case-Control Studies Hemostasis Immunology Emergency Medicine Female Surgery Burns business medicine.drug |
| Zdroj: | Burns. 42:1528-1533 |
| ISSN: | 0305-4179 |
| DOI: | 10.1016/j.burns.2016.04.013 |
| Popis: | The goal of this research was to study the influence of erythrocyte-derived microvesicles on hemostasis parameters during burn. It was found that the number of microvesicles derived from washed erythrocytes of burn patients after 1 day of storage at 37°C was 4.2 times bigger than the number of microvesicles derived from erythrocytes of healthy donors. Hemocoagulation properties of erythrocyte-derived microvesicles of burn patients also change: according to the results of thromboelastography their procoagulant activity increases significantly, at the same time their antithrombin and fibrinilytic activity decrease. Thus, we can conclude that hepercoagulation during burn is to a certain extent caused by the disruption of the balance between procoagulant activity of erythrocyte-derived microvesicles and their antithrombin and fibrinolytic activity. Hypercoagulation effect of erythrocyte-derived microvesicles increases during burn not just because of their changed properties but also due to their increased number after thermal trauma. |
| Databáze: | OpenAIRE |
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