Complement Components in the Diagnosis and Treatment after Kidney Transplantation—Is There a Missing Link?
Autor: | Maria Kapusta, Agnieszka Gala-Błądzińska, Beata Naumnik, Małgorzata Kielar, Marek Kuźniewski, Piotr Ceranowicz, Paulina Dumnicka, Beata Kuśnierz-Cabala, Grzegorz M Kubiak |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Graft Rejection Thrombotic microangiopathy medicine.medical_treatment kidney transplantation Review 030230 surgery allograft function Bioinformatics Biochemistry Microbiology 03 medical and health sciences 0302 clinical medicine medicine Humans complement Renal replacement therapy Molecular Biology Kidney transplantation Kidney business.industry Thrombotic Microangiopathies Graft Survival transplant rejection Complement System Proteins medicine.disease Allografts QR1-502 Complement system Transplant rejection 030104 developmental biology Immunosuppressive drug medicine.anatomical_structure surgical procedures operative complotypes Acute Disease business Immunosuppressive Agents Kidney disease |
Zdroj: | Biomolecules, Vol 11, Iss 773, p 773 (2021) Biomolecules |
Popis: | Currently, kidney transplantation is widely accepted as the renal replacement therapy allowing for the best quality of life and longest survival of patients developing end-stage renal disease. However, chronic transplant rejection, recurrence of previous kidney disease or newly acquired conditions, or immunosuppressive drug toxicity often lead to a deterioration of kidney allograft function over time. Complement components play an important role in the pathogenesis of kidney allograft impairment. Most studies on the role of complement in kidney graft function focus on humoral rejection; however, complement has also been associated with cell mediated rejection, post-transplant thrombotic microangiopathy, the recurrence of several glomerulopathies in the transplanted kidney, and transplant tolerance. Better understanding of the complement involvement in the transplanted kidney damage has led to the development of novel therapies that inhibit complement components and improve graft survival. The analysis of functional complotypes, based on the genotype of both graft recipient and donor, may become a valuable tool for assessing the risk of acute transplant rejection. The review summarizes current knowledge on the pathomechanisms of complement activation following kidney transplantation and the resulting diagnostic and therapeutic possibilities. |
Databáze: | OpenAIRE |
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