Timing embryo biopsy for PGD – before or after cryopreservation?

Autor:	Tamar Schwartz, Shiri Shinar, N. Mey-Raz, Joseph Hasson, Hadar Amir, Tal Shavit, B. Almog, N Kornecki
Rok vydání:	2016
Předmět:	Adult 0301 basic medicine medicine.medical_specialty Time Factors animal structures Reproductive Techniques Assisted Biopsy Endocrinology Diabetes and Metabolism Biology Cryopreservation Andrology 03 medical and health sciences 0302 clinical medicine Endocrinology medicine Humans Preimplantation Diagnosis Retrospective Studies Slow freezing Gynecology 030219 obstetrics & reproductive medicine medicine.diagnostic_test Obstetrics and Gynecology Retrospective cohort study Embryo Blastomere Embryo biopsy Embryo Transfer Embryo transfer 030104 developmental biology embryonic structures Female
Zdroj:	Gynecological Endocrinology. 32:756-758
ISSN:	1473-0766 0951-3590
DOI:	10.1080/09513590.2016.1177010
Popis:	Pre-implantation genetic diagnosis (PGD) is required in order to screen and diagnose embryos of patients at risk of having a genetically affected offspring. A biopsy to diagnose the genetic profile of the embryo may be performed either before or after cryopreservation. The aim of this study was to determine which biopsy timing yields higher embryo survival rates.Retrospective cohort study of all PGD patients in a public IVF unit between 2010 and 2013. Inclusion criteria were patients with good-quality embryos available for cryopreservation by the slow freezing method. Embryos were divided into two groups: biopsy before and biopsy after cryopreservation. The primary outcome was embryo survival rates post thawing.Sixty-five patients met inclusion criteria. 145 embryos were biopsied before cryopreservation and 228 embryos were cryopreserved and biopsied after thawing. Embryo survival was significantly greater in the latter group (77% vs. 68%, p 0.0001).Cryopreservation preceding biopsy results in better embryo survival compared to biopsy before cryopreservation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46eb842331965a2c576a280343692129 https://doi.org/10.1080/09513590.2016.1177010 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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