Neonatal screening for congenital hypothyroidism in the Netherlands: Cognitive and motor outcome at 10 years of age
| Autor: | Thomas Vulsma, Martha A. Grootenhuis, Jan J. M. de Vijlder, Bob F. Last, Brenda M. Wiedijk, Libbe Kooistra, Caren I. Lanting, Ria W. G. Nijhuis-van der Sanden, Liesbeth van der Sluijs Veer, Marlies J. E. Kempers |
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| Přispěvatelé: | Clinical Developmental Psychology, Child and Adolescent Psychiatry & Psychosocial Care, Other Research, CCA -Cancer Center Amsterdam, APH - Amsterdam Public Health, Paediatric Endocrinology, TNO Kwaliteit van Leven |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Time Factors Endocrinology Diabetes and Metabolism Clinical Biochemistry Population Quality of nursing and allied health care [NCEBP 6] Intelligence Context (language use) Biochemistry Cohort Studies Endocrinology Neonatal Screening Jeugd en Gezondheid Internal medicine medicine Congenital Hypothyroidism Humans education Child Motor skill Netherlands education.field_of_study Intelligence quotient business.industry Endocrinology and reproduction [UMCN 5.2] Biochemistry (medical) Infant Newborn Cognition medicine.disease Congenital hypothyroidism Quality of Care [EBP 4] Thyroxine Genetic defects of metabolism [UMCN 5.1] Health Motor Skills motor performance Cohort Female business Cohort study Follow-Up Studies |
| Zdroj: | Journal of Clinical Endocrinology and Metabolism, 912(3). Oxford University Press Journal of Clinical Endocrinology and Metabolism, 92, 919-24 Journal of clinical endocrinology and metabolism, 92(3), 919-924. The Endocrine Society Journal of Clinical Endocrinology and Metabolism, 92, 3, pp. 919-24 Kempers, M J, van der Sluijs-Veer, L, Nijhuis-van der Sanden, M W, Lanting, C I, Kooistra, L, Wiedijk, M, Last, B F, de Vijlder, J J, Grootenhuis, M A & Vulsma, T 2006, ' Neonatal screening for congenital hypothyroidism in the Netherlands: Cognitive and motor outcome at 10 years of age ', Journal of Clinical Endocrinology and Metabolism, vol. 912, no. 3, pp. 919 . https://doi.org/10.1210/jc.2006-1538 Journal of Clinical Endocrinology and Metabolism, 3, 92, 919-924 |
| ISSN: | 0021-972X |
| Popis: | Context: Patients with thyroidal congenital hypothyroidism (CH-T) born in The Netherlands in 1981–1982 showed persistent intellectual and motor deficits during childhood and adulthood, despite initiation of T4 supplementation at a median age of 28 d after birth. Objective: The present study examined whether advancement of treatment initiation to 20 d had resulted in improved cognitive and motor outcome. Design/Setting/Patients: In 82 Dutch CH-T patients, born in 1992 to 1993 and treated at a median age of 20 d (mean, 22 d; range, 2–73 d), cognitive and motor outcome was assessed (mean age, 10.5 yr; range, 9.6–11.4 yr). Severity of CH-T was classified according to pretreatment free T4 concentration. Main Outcome Measure: Cognitive and motor outcome of the 1992–1993 cohort in comparison to the 1981 to 1982 cohort was the main outcome measure. Results: Patients with severe CH-T had lower full-scale (93.7), verbal (94.9), and performance (93.9) IQ scores than the normative population (P < 0.05), whereas IQ scores of patients with moderate and mild CH-T were comparable to those of the normative population. In all three severity subgroups, significant motor problems were observed, most pronounced in the severe CH-T group. No correlations were found between starting day of treatment and IQ or motor outcome. Conclusions: Essentially, findings from the 1992–1993 cohort were similar to those of the 1981–1982 cohort. Apparently, advancing initiation of T4 supplementation from 28 to 20 d after birth did not result in improved cognitive or motor outcome in CH-T patients. |
| Databáze: | OpenAIRE |
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