Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin
Autor: | Francesca Gentili, William Vermi, Jean-Denis Franssen, Silvano Sozzani, Fabio Facchetti, Luisa Massardi, Elena Riboldi, Marc Parmentier, Simona Marrelli, Annunciata Vecchi, Alberto Mantovani, Valérie Wittamer, Marina Sironi, Walter Luini, David Communi |
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Rok vydání: | 2005 |
Předmět: |
RECRUITMENT
INTERFERON Langerhans cell Endothelium Lymphoid Tissue T cell Plasma Cells Immunology High endothelial venules LINE Biology Ligands CMKLR1 ENDOTHELIAL-CELLS CXCR3 LIGANDS CUTTING EDGE NODES TRAFFICKING ACTIVATION INHIBITOR Venules Cell Movement medicine Humans Lupus Erythematosus Systemic Immunology and Allergy Chemerin Myeloid Cells Cells Cultured Skin Venule Chemotactic Factors Brief Definitive Report Endothelial Cells hemic and immune systems Dendritic Cells Endothelial stem cell medicine.anatomical_structure Cancer research biology.protein Intercellular Signaling Peptides and Proteins Receptors Chemokine Chemokines |
Zdroj: | The Journal of Experimental Medicine |
ISSN: | 1540-9538 0022-1007 |
Popis: | Chemerin is a chemotactic agent that was recently identified as the ligand of ChemR23, a serpentine receptor expressed by activated macrophages and monocyte-derived dendritic cells (DCs). This paper shows that blood plasmacytoid and myeloid DCs express functional ChemR23. Recombinant chemerin induced the transmigration of plasmacytoid and myeloid DCs across an endothelial cell monolayer. In secondary lymphoid organs (lymph nodes and tonsils), ChemR23 is expressed by CD123+ plasmacytoid DCs and by CD1a+ DC-SIGN+ DCs in the interfollicular T cell area. ChemR23+ DCs were also observed in dermis from normal skin, whereas Langerhans cells were negative. Chemerin expression was selectively detected on the luminal side of high endothelial venules in secondary lymphoid organs and in dermal endothelial vessels of lupus erythematosus skin lesions. Chemerin+ endothelial cells were surrounded by ChemR23+ plasmacytoid DCs. Thus, ChemR23 is expressed and functional in plasmacytoid DCs, a property shared only by CXCR4 among chemotactic receptors. This finding, together with the selective expression of the cognate ligand on the luminal side of high endothelial venules and inflamed endothelium, suggests a key role of the ChemR23/chemerin axis in directing plasmacytoid DC trafficking. |
Databáze: | OpenAIRE |
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