Omeprazole plus azithromycin and either amoxicillin or tinidazole for eradication of Helicobacter pylori infection
| Autor: | George K Anagnostopoulos, George Margantinis, Stavros Tsiakos, Panagiotis Kostopoulos, Dimitrios Arvanitidis |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Gastrointestinal Diseases Rapid urease test Azithromycin Gastroenterology Drug Administration Schedule Tinidazole Helicobacter Infections Internal medicine Medicine Humans Prospective Studies Omeprazole Antibacterial agent Aged Probability Intention-to-treat analysis biology Dose-Response Relationship Drug Helicobacter pylori business.industry Amoxicillin Middle Aged biology.organism_classification Surgery Treatment Outcome Drug Therapy Combination Female business medicine.drug Follow-Up Studies |
| Zdroj: | Journal of clinical gastroenterology. 36(4) |
| ISSN: | 0192-0790 |
| Popis: | Goals: To establish whether omeprazole plus azithromycin in association with either amoxicillin or tinidazole is effective in curing Helicobacter pylori infection in dyspeptic patients. Background: Many antibiotics in combination with antisecretory drugs have been used in an attempt to find the optimal regimen for eradication of H. pylori. Azithromycin is a macrolide that achieves high concentrations in gastric tissue after a single 500-mg oral dose. Study: A total of 160 consecutive symptomatic patients with H. pylori received omeprazole 20 mg twice daily for I week, azithromycin 500 mg/d for 3 days, and were randomly assigned to either amoxicillin I g twice daily (OAzAm group, n = 80) for I week or tinidazole 500 mg twice daily for 3 days (OAzT group, n = 80). H. pylori status was assessed by rapid urease test and histology at entry and by histology and 13 C-urea breath test after the end of the therapy. Results: H. pylori was eradicated in 62.5% of patients in the OAzAm group (intention to treat [ITT] 62.5%) and in 71.2% of patients in the OAzT group (ITT 71.2%). Conclusions: Although the compliance was excellent and the side effects negligible, the regimens used were partially effective for the eradication of H. pylori. |
| Databáze: | OpenAIRE |
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