Anti-inflammatory and immunologically active polysaccharides of Sedum telephium
| Autor: | Nadia Mulinacci, Hildebert Wagner, A. Sendl, Franco Francesco Vincieri |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Sedum telephium
Magnetic Resonance Spectroscopy medicine.drug_class Molecular Sequence Data Carbohydrates Plant Science Horticulture Biology Polysaccharide Biochemistry Gas Chromatography-Mass Spectrometry Anti-inflammatory Mice Phagocytosis Polysaccharides Botany medicine Animals Molecular Biology chemistry.chemical_classification Complement Inactivator Proteins Traditional medicine Tumor Necrosis Factor-alpha Anti-Inflammatory Agents Non-Steroidal General Medicine Plants biology.organism_classification Rats Crassulaceae Carbohydrate Sequence chemistry |
| Zdroj: | Phytochemistry. 34:1357-1362 |
| ISSN: | 0031-9422 |
| DOI: | 10.1016/0031-9422(91)80029-z |
| Popis: | Two major polysaccharides, rhamnogalacturonans with mean M(r)s of 13,500 and 13,000, were isolated from dried leaves of Sedum telephium by column chromatography on DEAE-Sepharose CL-6B and gel filtration on Fractogel TSK HW-50 (S) and Sephacryl 200 HR. The structures were determined mainly by NMR spectroscopy, methylation analysis and GC-MS of the partially methylated alditol acetates, carboxyl reduction and by analysis of acidic and enzymatic degradation products. Both polysaccharides exert an anticomplementary effect in vitro, induce TNF-alpha-production, enhance phagocytosis in vitro and in vivo, and exhibit anti-inflammatory activity. |
| Databáze: | OpenAIRE |
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