An Enhanced β Turn in Water
| Autor: | Benben Song, Amit K. Galande, Martha G. Bomar, Krishna Kodukula, Patrick Kibler |
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| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Organic Letters. 13:5878-5881 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/ol2024983 |
| Popis: | Aiming to design short linear peptides featuring strong intramolecular hydrogen bonds in water, a series of tetrapeptides based on the sequence Ac-Ala-Pro-Ala-Ala-NH(2) containing all possible combinations of L- and D-amino acids was synthesized. A regiospecific combination of heterochiral residues (DDLL or its mirror image LLDD) can be used to increase turn formation and stability within short peptides in water. |
| Databáze: | OpenAIRE |
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