Contrast-enhanced ultrasound for the assessment of focal nodular hyperplasia - results of a multicentre study
| Autor: | Simona Ioanițescu, Adrian Saftoiu, Daniela Larisa Sandulescu, Dana Nedelcu, Cristina Cijevschi, Catalina Mihai, Alina Popescu, Nicoleta Iacob, Roxana Sirli, Zeno Spârchez, Grațian Miclăuș, Tudor Moga, Ciprian Brisc, Radu Badea, Mirela Danila, Ioan Sporea |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Acoustics and Ultrasonics
Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Ultrasound Liver Neoplasms Focal nodular hyperplasia Contrast Media medicine.disease Predictive value Magnetic Resonance Imaging Diagnosis Differential Late phase Focal Nodular Hyperplasia Biopsy Medicine Humans Radiology Nuclear Medicine and imaging business Nuclear medicine Mechanical index Contrast-enhanced ultrasound Arterial phase Ultrasonography |
| Zdroj: | Medical ultrasonography. 23(2) |
| ISSN: | 2066-8643 |
| Popis: | Aim : Contrast-enhanced ultrasound (CEUS) has become a relevant imaging method for the evaluation of focal liver le- sions (FLL). The aim of this study was to evaluate the performance of CEUS for the assessment of focal nodular hyperplasia (FNH) in a large study group. Material and methods : We performed a multicentre prospective observational study, which included successive CEUS examinations from fourteen Romanian centres. CEUS examinations were performed in de novo FLL, using low mechanical index ultrasound, following an intravenous bolus of 2.4 ml SonoVue. CEUS was considered conclusive for FNH if a typical pattern was present following contrast (rapid “spoke-wheel” enhancement during the arterial phase, hyperenhanced lesion during venous phase, hyper- or isoenhanced in the late phase). In all cases a reference method was available (contrast enhanced CT or MRI or biopsy). The trial was registered in clinicaltrials.gov (Identifier NCT01329458). Results : During the 6 years study, 2062 “de novo” FLL were evaluated by CEUS. From this cohort, 94/2062 (4.5%) had a typical enhancing pattern for FNH as described in the EFSUMB guidelines. Contrast enhanced CT/MRI and biopsy diagnosed additional 15 FNH. From the 94 cases diagnosed as FNH by CEUS, in nine the final diagnosis was different (five of them adenomas). CEUS had 85% sensitivity, 99.5% specificity, 90.4% positive predictive value, 99.2% negative predictive value and 98.8% diagnostic accuracy for the diagnosis of FNH. Conclusions : CEUS is a sensitive and very specific method for the diagnosis of FNH. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|