Microscopic Infiltration of Cryopreserved Ovarian Tissue in 2 Patients With Ewing Sarcoma
| Autor: | Christophe Chantrain, Pierre Philippet, Stefan Schifflers, Christine Galant, Katty Delbecque, Nadine Francotte |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pathology
medicine.medical_specialty Adolescent CD99 Cancer relapse Bone Neoplasms Sarcoma Ewing Cryopreservation Metastasis 03 medical and health sciences 0302 clinical medicine medicine Humans Ovarian tissue cryopreservation Child Ovarian Neoplasms 030219 obstetrics & reproductive medicine business.industry Ovarian tissue Fertility Preservation Hematology medicine.disease Oncology 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Female Sarcoma business Infiltration (medical) |
| Zdroj: | Journal of Pediatric Hematology/Oncology. 40:e167-e170 |
| ISSN: | 1077-4114 |
| Popis: | We report the clinical history of 2 female patients with Ewing sarcoma and microscopic ovarian infiltration. In both cases, the initial workup found no metastasis. However, the examination of cryopreserved ovarian tissues revealed the presence of CD99 positive tumor cells with rearrangement of EWS gene confirmed by FISH. Both children were treated as patients with localized tumor and are currently in remission. These reports underline that, in Ewing sarcoma patients, retransplantation of cryopreserved ovarian tissue is not harmless and could lead to cancer relapse. These observations question also on the significance of ovarian dissemination on Ewing sarcoma prognosis and therapy. |
| Databáze: | OpenAIRE |
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