The peridural membrane of the spine has characteristics of synovium
| Autor: | Petar N. Grozdanov, Hemmo A. Bosscher, Clinton C. MacDonald, Miles Day, Irfan I. Warraich |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Epidural Space
Male musculoskeletal diseases 0301 basic medicine Pathology medicine.medical_specialty Histology Dura mater Antigens Differentiation Myelomonocytic 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Antigens CD Hyaluronic acid medicine Humans Spinal canal Ecology Evolution Behavior and Systematics Basement membrane CD55 Antigens business.industry Synovial Membrane Middle Aged musculoskeletal system Spine Epidural space Hyaluronan Receptors 030104 developmental biology medicine.anatomical_structure chemistry Female Tunica Anatomy Synovial membrane business 030217 neurology & neurosurgery Biotechnology |
| Zdroj: | The Anatomical Record. 304:631-646 |
| ISSN: | 1932-8494 1932-8486 |
| DOI: | 10.1002/ar.24474 |
| Popis: | The peridural membrane (PDM) is a well-defined structure between dura mater and the wall of the spinal canal. The spine may be viewed as a multi-segmented joint, with the epidural cavity and neural foramina as joint spaces and PDM as synovial lining. The objective of this investigation was to determine if PDM has histological characteristics of synovium. Samples of the PDM of the thoraco-lumbar spine were taken from 23 human cadavers and analyzed with conventional light microscopy and confocal microscopy. Results were compared to reports on similar analyses of synovium in the literature. Histological distribution of areolar, fibrous, and adipose connective tissue in PDM was similar to synovium. The PDM has an intima and sub-intima. No basement membrane was identified. CD68, a marker for macrophage-like-synoviocytes, and CD55, a marker for fibroblast-like synoviocytes, were seen in the lining and sub-lining of the PDM. Multifunctional hyaluronan receptor CD44 and hyaluronic acid synthetase 2 marker HAS2 were abundantly present throughout the membrane. Marked presence of CD44, CD55, and HAS2 in the well-developed tunica muscularis of blood vessels and in the body of the PDM suggests a role in the maintenance and lubrication of the epidural cavity and neural foramina. Presence of CD68, CD55, and CD44 suggests a scavenging function and a role in the inflammatory response to noxious stimuli. Thus, the human PDM has histological and immunohistochemical characteristics of synovium. This suggests that the PDM may be important for the homeostasis of the flexible spine and the neural structures it contains. |
| Databáze: | OpenAIRE |
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