The role of astrocytes in prion-like mechanisms of neurodegeneration

Autor:	Phillip Smethurst, Hannah Franklin, Benjamin E Clarke, Katie Sidle, Rickie Patani
Rok vydání:	2022
Předmět:	Protein Aggregates Protein Folding Prions Astrocytes FOS: Clinical medicine Stem Cells Neurosciences Humans Neurodegenerative Diseases Cell Biology Neurology (clinical) Prion Diseases
Zdroj:	Brain. 145:17-26
ISSN:	1460-2156 0006-8950
DOI:	10.1093/brain/awab366
Popis:	Accumulating evidence suggests that neurodegenerative diseases are not merely neuronal in nature but comprise multicellular involvement, with astrocytes emerging as key players. The pathomechanisms of several neurodegenerative diseases involve the deposition of misfolded protein aggregates in neurons that have characteristic prion-like behaviours such as template-directed seeding, intercellular propagation, distinct conformational strains and protein-mediated toxicity. The role of astrocytes in dealing with these pathological prion-like protein aggregates and whether their responses either protect from or conspire with the disease process is currently unclear. Here we review the existing literature implicating astrocytes in multiple neurodegenerative proteinopathies with a focus on prion-like behaviour in this context.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e50e64da764242df8924a2b9f624de https://doi.org/10.1093/brain/awab366 Zobrazit plný text záznamu