Dual functions of CNS inflammation in food intake and metabolic regulation
| Autor: | Kimberly P. Kinzig, Sara L. Hargrave, Tien-Jui Lee |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
Male 0301 basic medicine medicine.medical_specialty Adipose tissue Inflammation Motor Activity Weight Gain Proinflammatory cytokine Rats Sprague-Dawley Eating 03 medical and health sciences 0302 clinical medicine Internal medicine Animals Medicine Molecular Biology Neuroinflammation Injections Intraventricular biology Tumor Necrosis Factor-alpha business.industry Angiotensin II General Neuroscience Body Weight Brain Rats Fatty acid synthase 030104 developmental biology Endocrinology biology.protein Tumor necrosis factor alpha Blood sugar regulation Neurology (clinical) Inflammation Mediators medicine.symptom Energy Metabolism business Weight gain 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Brain Research. 1740:146859 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/j.brainres.2020.146859 |
| Popis: | Western diet (WD) consumption induces chronic mild inflammation in the hypothalamus. However, metabolic consequences of increased hypothalamic inflammatory cytokines remain unclear. This research first aimed to examine whether increased proinflammatory cytokines in the brain influenced feeding or metabolism. Rats that received an intracerebroventricular third ventricle injection (i3vt) of 0.5 pg TNFα daily for six days consumed significantly more calories than saline-injected rats, with no differences between treatment groups in terms of body weight, blood triglycerides nor glucose regulation. Continuously infusing TNFα for three weeks decreased hepatic fatty acid synthase (FAS) and increased body weight and the epididymal adipose sterol regulatory element-binding protein 1c (SREBP-1c) gene expression. Differences were not due to food intake nor voluntary wheel running activity. The second aim of this research was to examine whether inhibition of inflammation signaling in the brain at early stage of switching from chow to WD would affect diet-induced obesity development. WD-fed rats with i3vt NFκB inhibitor had greater caloric intake than rats given i3vt saline. These studies suggest elevated inflammatory cytokines in the brain induce food intake acutely and favor fat storage and weight gain in the long term. However, in the early stage of WD consumption, hypothalamic inflammatory signaling inhibits caloric intake and may serve as a warning signal of energy imbalance. |
| Databáze: | OpenAIRE |
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