Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease
| Autor: | Bang V. Bui, Sophie Chevalier, Sylvain Beaulieu, Christopher Fowler, Marc-André Rhéaume, Christopher C. Rowe, Xavier Hadoux, Jean Daniel Arbour, Pedro Rosa-Neto, Peter van Wijngaarden, Victor L. Villemagne, Jean-Paul Soucy, Robert Williamson, Edward N. Taylor, Serge Gauthier, Jonathan G Crowston, Christine T. O. Nguyen, Flora Hui, Jeremiah K.H. Lim, Colin L. Masters, Jason Ha, Christopher J. Fluke, Ziad S. Nasreddine, Mohamed Dirani, Alice Pébay, Frédéric Lesage, Samantha M Loi, Jean-Philippe Sylvestre, Sulantha Mathotaarachchi |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Pathology General Physics and Astronomy Cohort Studies chemistry.chemical_compound Mice 0302 clinical medicine Amyloid precursor protein Medicine lcsh:Science Multidisciplinary biology Brain Alzheimer's disease Middle Aged medicine.anatomical_structure Biomarker (medicine) Female Tomography Optical Coherence medicine.medical_specialty Amyloid beta Science Mice Transgenic General Biochemistry Genetics and Molecular Biology Article Retina 03 medical and health sciences In vivo Alzheimer Disease Dementia Animals Humans Aged Amyloid beta-Peptides business.industry Retinal General Chemistry medicine.disease Mice Inbred C57BL 030104 developmental biology chemistry Positron-Emission Tomography biology.protein lcsh:Q business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Nature Communications Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019) |
| ISSN: | 2041-1723 |
| Popis: | Studies of rodent models of Alzheimer’s disease (AD) and of human tissues suggest that the retinal changes that occur in AD, including the accumulation of amyloid beta (Aβ), may serve as surrogate markers of brain Aβ levels. As Aβ has a wavelength-dependent effect on light scatter, we investigate the potential for in vivo retinal hyperspectral imaging to serve as a biomarker of brain Aβ. Significant differences in the retinal reflectance spectra are found between individuals with high Aβ burden on brain PET imaging and mild cognitive impairment (n = 15), and age-matched PET-negative controls (n = 20). Retinal imaging scores are correlated with brain Aβ loads. The findings are validated in an independent cohort, using a second hyperspectral camera. A similar spectral difference is found between control and 5xFAD transgenic mice that accumulate Aβ in the brain and retina. These findings indicate that retinal hyperspectral imaging may predict brain Aβ load. The use of PET for detection of Aβ in the brain in AD has limitations; studies also indicate that retinal changes, including Aβ deposition, occur in AD. Here the authors demonstrate the potential to use in vivo retinal hyperspectral imaging as a surrogate for brain accumulation of Aβ. |
| Databáze: | OpenAIRE |
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