Increased prevalence of celiac disease in idiopathic inflammatory myopathies

Autor:	Charlotte Dahle, Claes Hallert, Olof Danielsson, Magnus Vrethem, Björn Lindvall
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	Adult Male medicine.medical_specialty Pathology Neurologi idiopathic inflammatory myopathies Biopsy Population prevalence Disease Malignancy Gastroenterology Antibodies Gliadin Inflammatory myopathy Cohort Studies 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Internal medicine Neoplasms Intestine Small Medicine Humans education Myositis Original Research Aged 030203 arthritis & rheumatology Sweden education.field_of_study business.industry Incidence (epidemiology) Incidence Muscle Smooth Middle Aged Endomysium medicine.disease Celiac Disease medicine.anatomical_structure Neurology Cohort celiac disease incidence myositis Female business 030217 neurology & neurosurgery
Zdroj:	Brain and Behavior
ISSN:	2162-3279
Popis:	ObjectivesIdiopathic inflammatory myopathies (IIM) are often associated with other immune-mediated diseases or malignancy. Some studies have reported a high frequency of celiac disease in IIM. The aim of this study was to investigate the prevalence of celiac disease, systemic inflammatory diseases, and malignancy in a cohort of IIM patients, and estimate the incidence of IIM in the county of ostergotland, Sweden. Material and MethodsWe reviewed medical records and analyzed sera from 106 patients, fulfilling pathological criteria of inflammatory myopathy, for the presence of IgA antibodies against endomysium and gliadin. Antibody-positive patients were offered further investigation with small bowel biopsy or investigation for the presence of antibodies against antitissue transglutaminase (t-TG). The patients were classified according to Bohan and Peter or Griggs criteria. The presence of celiac disease, systemic inflammatory, and malignant diseases was documented. ResultsFour of 88 patients classified as IIM (4.5%) had biopsy-confirmed celiac disease, which is higher than the prevalence in the general population, detected with a similar screening procedure (0.53%). Thirty-three patients (38%) had a systemic inflammatory disease and five (5.7%) a malignancy. The incidence of confirmed IIM in the county of ostergotland was 7.3 per million/year. ConclusionsThe results highlight the high frequency of associated inflammatory and malignant diseases and confirm an increased prevalence of celiac disease in IIM. Funding Agencies|Linkoping University; Region Ostergotland
Databáze:	OpenAIRE
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