Delineation of Two Clinically and Molecularly Distinct Subgroups of Posterior Fossa Ependymoma
| Autor: | Martin Sill, Till Milde, Wiesia Grajkowska, Cynthia Hawkins, Axel Benner, David T.W. Jones, Andreas von Deimling, Hendrik Witt, Michael D. Taylor, Livia Garzia, Ruth Isserlin, Andrey Korshunov, Sebastian Bender, Marc Remke, Stephen C. Mack, Thomas Hielscher, Uri Tabori, Kelsey C. Bertrand, Paul A. Northcott, Yuan Yao, Stefan M. Pfister, Yoon Jae Cho, James T. Rutka, Andrea Wittmann, Stephen S. Roberts, Abhijit Guha, Tim Van Meter, William A. Weiss, Nalin Gupta, Luca Massimi, Marina Ryzhova, Andreas E. Kulozik, Gary D. Bader, Olaf Witt, Boleslaw Lach, Peter Lichter |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Ependymoma Cancer Research Pathology medicine.medical_specialty Disease Biology Article Metastasis medicine Humans Pediatric ependymoma Chromosome Aberrations Tissue microarray Brain Neoplasms Gene Expression Profiling Cell Biology Anatomy Middle Aged medicine.disease Gene expression profiling Cranial Fossa Posterior Oncology Cohort Immunohistochemistry Female |
| Zdroj: | Cancer Cell. 20:143-157 |
| ISSN: | 1535-6108 |
| Popis: | SummaryDespite the histological similarity of ependymomas from throughout the neuroaxis, the disease likely comprises multiple independent entities, each with a distinct molecular pathogenesis. Transcriptional profiling of two large independent cohorts of ependymoma reveals the existence of two demographically, transcriptionally, genetically, and clinically distinct groups of posterior fossa (PF) ependymomas. Group A patients are younger, have laterally located tumors with a balanced genome, and are much more likely to exhibit recurrence, metastasis at recurrence, and death compared with Group B patients. Identification and optimization of immunohistochemical (IHC) markers for PF ependymoma subgroups allowed validation of our findings on a third independent cohort, using a human ependymoma tissue microarray, and provides a tool for prospective prognostication and stratification of PF ependymoma patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|