Development of Building Blocks for the Synthesis of N-Heterocyclic Carbene Ligands
| Autor: | Guopin Xu, Scott R. Gilbertson |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
chemistry.chemical_classification
Molecular Structure Organic Chemistry chemistry.chemical_element Ligands Biochemistry Combinatorial chemistry Catalysis Hydrocarbons Amino acid chemistry.chemical_compound Suzuki reaction chemistry Heterocyclic Compounds Side chain Peptide synthesis Molecule Amino Acids Physical and Theoretical Chemistry Methane Carbene Palladium |
| Zdroj: | Organic Letters. 7:4605-4608 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/ol0516521 |
| Popis: | [reaction: see text] The synthesis of a series of NHC building blocks that can then be incorporated into more complicated structures by palladium catalysis is reported. This approach is used for the synthesis of three amino acids containing NHC side chains. The ability to use the amino acids in solid-phase peptide synthesis to make NHC-containing peptides is also demonstrated. Additionally, the NHC side chain can be deprotected and coordinated to a catalytically active transition metal. Finally, it is illustrated that the building blocks participate in Suzuki coupling to provide access to substituted NHC ligands. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|